Handbook of Neurochemistry and Molecular Neurobiology Neuroimmunology
Abel Lajtha, Armen Galoyan, Hugo Besedovsky
This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain.
Категории:
Год:
2008
Издание:
3rd
Издательство:
Springer
Язык:
english
Страницы:
495
ISBN 10:
0387303588
ISBN 13:
9780387303581
Файл:
PDF, 5.84 MB
IPFS:
,
english, 2008
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